Vitoli Healthy Aging and Vitoli Synergy: Next-Generation Anti-Aging Products

Vitoli Healthy Aging combines two well-studied ingredients selected during our research with Concordia University.

Healthy Aging Synergy goes further by adding a promising combination identified in our research, protected by our Canadian patent, in addition to two other ingredients that increase the impact on the modulation of mTOR to slow cellular aging. It is a more expensive product, intended for people who want what is most effective for slowing cellular aging.

Vitoli Healthy Aging Synergy contains highly bioavailable curcumin and alpha-lipoic acid, which are two other mTOR modulators; a protein that plays a crucial role in the regulation of cellular aging and that should be repressed. This product also contains the synergy, protected by patent, of a molecule coming from a passionflower extract, together with molecules from Japanese knotweed extract. During our research with Concordia University, we demonstrated that this synergy, the most powerful identified so far, has a very large beneficial impact on mitochondria.

The dosage of Vitoli Healthy Aging Synergy is two capsules per day versus one for Vitoli Healthy Aging because the optimal quantity required was too large to fit into a single capsule. Hence the reason for the 60-capsule format for one month.

1. Product Summary

Vitoli Healthy Aging = VHA = Hydroxytyrosol (Provitol^MD Complex) + Resveratrol from a selected extract of Japanese knotweed.
Vitoli Healthy Aging Synergy = VHAS = Hydroxytyrosol (Provitol^MD Complex) + Resveratrol from a selected extract of Japanese knotweed + Curcumin (Longvida®; 65 times more absorbable) + R-alpha-lipoic acid + a particular Passionflower extract.

2. Impact of Ingredients on Aging

2.1) Hydroxytyrosol (Provitol^MD Complex)

Menendez et al, 2013; de Pablos et al, 2019, Simao et al, 2023; Arangia et al, 2023; D’Angelo et al, 2001;Gallardo-Fernández et al, 2023; Frumuzachi et al, 2025; Roberts et al, 2023; Millman et al, 2021; Micheli et al,2023; Wen et al, 2024; Elmaksoud et al, 2021; Song et al, 2024; Terracina et al, 2022; Morkovin et al, 2024; Illescaet al, 2019; Gamal et al, 2025; Serreli et al, 2024; Fytili et al, 2022; Simao et al, 2023.

Present in both products – the Provitol^MD Complex exclusive to Vitoli products is a group of polyphenols extracted directly from selected olives in Spain using patented technology.

🔹Excellent bioavailability

Easily absorbed at the intestinal level (95%), it enters the bloodstream within 5 to 30 minutes for a period of 5 to 6 hours. It binds to blood lipoproteins and reduces their oxidation and is easily distributed throughout different organs such as the kidneys, liver, muscles, lungs and heart. Hydroxytyrosol is one of the rare polyphenols able to cross the blood-brain barrier and to have an antioxidant and anti-inflammatory action at the brain level (which could play a role in preventing nerve degeneration). It interacts with dopamine metabolism and could have preventive effects on Lewy body dementia.

🔹Next-generation anti-aging

Hydroxytyrosol is a gerosuppressor; it acts on the mechanisms of primary aging (Menendez et al., 2013; de Pablos et al., 2019). Given that these are the same cellular mechanisms as fasting, it constitutes an important ally to improve its benefits. With resveratrol, it allows complete metabolic impacts that may be useful for both performance and body composition (Roberts et al., 2023; Fytili et al., 2022).

🔹Powerful antioxidant

Helps neutralize free radicals — molecules responsible for oxidative stress, one of the main drivers of cellular aging. It acts by stimulating the natural antioxidant production of cells (10 related mechanisms of action including increased glutathione). Protects against oxidative damage to lipids, proteins and DNA, which accumulate with age.

🔹Cardiometabolic health

The Provitol^MD Complex, containing hydroxytyrosol, is used in each of the Vitoli products at the dose recommended by the European Union for reducing the risks of atherosclerosis. Based on a recent meta-analysis grouping 14 clinical studies on supplementation, it is possible to state that it allows a significant reduction in total cholesterol, triglycerides and insulin (Frumuzachi et al, 2025).

🔹Improvement of digestive health

Hydroxytyrosol may help repair the intestinal barrier in cases of intestinal permeability, it reduces intestinal inflammation, oxidation and apoptosis caused by ulcerative colitis. It reduces intestinal oxidation and inflammation by improving bile metabolism (among other things) and reduces intestinal oxidation through modulation of Nrf2 and mitophagy. It also improves the composition of the microbiota (Arangia et al, 2023; Millman et al, 2021;Micheli et al, 2023; Simao et al, 2023, Song et al, 2024).

🔹Regulation of inflammation

Hydroxytyrosol can reduce pro-inflammatory mediators and inhibit pathways related to the chronic inflammatory reaction, often associated with “inflammaging.” This could reduce the speed of progression or the risks of development, or even the complications, related to inflammatory diseases.

🔹Other effects related to aging

Preclinical data suggest that it can influence mechanisms such as autophagy (cellular cleaning; 7 related mechanisms of action) and mitochondrial function (7 related mechanisms of action), which can help maintain energy, cell survival and improved metabolism. The impacts on mitochondria could explain, at least in part, the improvements observed in clinical studies on physical performance (Roberts et al., 2023).

2.2) Resveratrol (natural, extract from Japanese knotweed)

Terracina et al, 2022; Morkovin et al, 2024; Hou et al, 2019; Allard et al, 2009; Kaeberlein, 2010; Kelly et al, 2010;Moussa et al, 2017, Bastianetto et al, 2014; Rahvar et al, 2011, Wiciński et al, 2017, Hoseini et al, 2019; Witte et al, 2014; Griñán-Ferré et al, 2021; Bhullar et Hubbard, 2015; Vang et al, 2011; Novelle et al, 2015; Eric Simard, 2016;Wang et al, 2020; Cai et al, 2020.

To date, resveratrol alone accounts for more than 5,000 scientific publications. One study concluded that the best alternative to caloric restriction in humans would be to reduce our caloric intake, exercise regularly and consume a resveratrol dietary supplement.

Resveratrol is a polyphenol, a stilbene, found in many plants, including peanuts and several berries. Although it is known for its presence in red wine, it was initially isolated in 1939 from a plant in Japan. Subsequently, it was isolated from a second Japanese plant well known for its use in traditional Chinese and Indian medicine: Japanese knotweed. In 1993, it was isolated from red wine (present in small amounts).

About twenty clinical studies describe the pharmacokinetics of resveratrol in humans. Its highest level of blood concentration appears after 30 to 90 minutes. Its half-life is about nine hours. About 70% of the consumed dose is absorbed, but only small quantities of the intact molecule are detectable in the blood. The extremely rapid conjugation metabolism (binding to other molecules) explains this phenomenon. However, recent studies have shown that these same metabolites (conjugated molecules) accumulate in different tissues of the body and allow the health benefits.

🔹Functional bioavailability

Taking it with a meal containing lipids or in association with synergistic polyphenols (e.g. olive polyphenols) increases its functional bioavailability. Regular intake allows a cumulative effect on cellular pathways.

🔹Toxicity

Just because a molecule is natural does not necessarily mean it is safe. Thus, the potential toxicity of resveratrol was studied. It is a very safe molecule. Resveratrol, even at doses of 1500 mg per day, has not caused notable adverse effects.
Quebec research
Our research with Concordia University demonstrated that resveratrol, from Japanese knotweed, provides a very powerful synergistic effect with other gerosuppressor such as the Provitol^MD Complex in Vitoli products.

🔹Antioxidant activity

Protects cells against oxidative damage and inflammation, promoting a healthier cellular environment. Like the olive polyphenols of the exclusive Provitol^MD Complex, it activates endogenous antioxidant enzymes (the natural antioxidant production of cells), protects mitochondria and reduces chronic oxidative damage.

🔹Longevity pathways

Resveratrol is a gerosuppressor like the Provitol^MD Complex. It acts on the mechanisms of primary aging and activates proteins related to longevity such as sirtuins and metabolic pathways like those observed with caloric restriction or fasting. It also helps maintain genomic stability. Used alone, its impacts are significant, but weak. Our research work with Concordia University has however demonstrated that it is a powerful synergistic ally in combination with other gerosuppressors and geroprotectors as is the case in Vitoli Healthy Aging and Vitoli Healthy Aging Synergy.

🔹Mitochondrial function

It can improve mitochondrial health, supporting cellular energy and resistance to stress. It may stimulate mitochondrial biogenesis. This would explain its positive impacts on sports performance and body composition, specifically at the level of brown fat, which is beneficial for health.

🔹Improvement of metabolism

Many clinical studies confirm its beneficial effects on improving metabolism and body composition. Its impacts on epigenetic remodeling could even help redirect negative trends related to or leading to weight gain and metabolic syndrome. It improves type 2 diabetes parameters: blood sugar, Chol/HDL, HDL, antioxidant capacity and insulin sensitivity (Hou et al., 2019).

🔹Cardiovascular health

Resveratrol is associated with a vasorelaxant effect (to reduce hypertension) and a slight antiplatelet effect (to prevent blockage of arteries). It reduces the proliferation of vascular smooth muscle cells, a process involved in atherosclerosis (blockage of arteries). It stimulates the endothelial nitric oxide synthase enzyme (eNOS), which improves the production of nitric oxide, a known vasodilator (which would explain its blood-pressure-lowering effect). It decreases the expression of adhesion molecules, a process involved in plaque formation that can cause blockage of arteries. In short, a series of small effects which, when combined, have the possibility of improving heart health.

🔹Cognitive health

Researchers also measured cerebral circulation by imaging before and 45 minutes after consumption. Taking resveratrol had a significant effect, depending on the dose, in increasing blood flow to the brain. It may increase the expression of the BDNF gene (for the development of neuronal connections), improves endothelial function, supports cerebral blood flow and presents indirect neuroprotective effects.

🔹Reduction of inflammation

Resveratrol inhibits certain enzymes associated with inflammation such as cyclooxygenases (COX) and lipoxygenases (LOX). In addition, it may inhibit transcription factors of inflammation such as NFκB or AP-1. Thus, some beneficial effects of resveratrol may come from its anti-inflammatory effects. We know, among other things, that one of the factors of premature aging is precisely inflammation. Likewise, the benefits of resveratrol on diabetes and obesity are partly linked to its anti-inflammatory effects.

🔹Microbiota

Resveratrol modifies the composition of the intestinal microbiota, often observed in animal models of dysbiosis induced by a high-fat diet, for example by increasing beneficial bacteria and reducing species associated with inflammation or obesity. In studies in diabetic mice, resveratrol reverses certain microbial imbalances (such as Bacteroides, Alistipes) and improves intestinal permeability.

🔹Hormones

Resveratrol has a particular behavior. It seems to have an effect that changes depending on the environment and the presence of estrogens. Thus, in the absence of 17-beta-estradiol, resveratrol acts as an agonist, but in its presence, it acts as an antagonist. Therefore, it could have a normalizing effect on hormone receptors and potentially be protective against hormone-dependent cancers such as breast cancer.

2.3) R-alpha-lipoic acid (only in Vitoli Healthy Aging Synergy)

Superti and Russo, 2024; Carnib et al., 2025; Vajdi and Abbasalizad Farhangi, 2020; Han et al., 2012; Akbari et al., 2018; Packer et al., 1995; Shay et al., 2009.

Alpha-lipoic acid is an antioxidant naturally produced by the body and available through food or supplements. It plays a key role in energy metabolism (in the mitochondria) and has antioxidant and anti-inflammatory properties.

🔹Metabolic antioxidant

Works inside the mitochondria, the cell’s “powerhouse,” to reduce oxidative stress and regenerate other endogenous antioxidants. In addition to neutralizing free radicals, it helps recycle other antioxidants such as vitamin C, vitamin E and glutathione.

🔹Energy metabolism & reduction of glycemic stress

Plays a role in carbohydrate and lipid metabolism, potentially favorable to metabolic health over time. A meta-analysis indicates that ALA supplementation significantly reduces inflammatory markers such as CRP, IL-6 and TNF-α in patients with metabolic disorders. In addition, a meta-analysis suggests a slight reduction in body weight and BMI with ALA compared to placebo, but the effect is moderate.

🔹Impact on the brain and nervous system

Several trials and a meta-analysis show that ALA may improve nerve conduction and reduce symptoms of diabetic peripheral neuropathy (tingling, pain).

N.B. It adds an additional metabolic dimension and an energy dimension to the anti-aging approach of Healthy Aging Synergy.

2.4) Highly bioavailable curcumin (only in Vitoli Healthy Aging Synergy)

Eric Simard, 2016; Hewlings and Kalman, 2017; Dehzad et al., 2023; Jafari et al., 2024; Liu et al., 2022; Bhat, 2019; Izadi et al., 2024; Zia et al., 2021.

It has been used for medical treatments in Asia for more than 2,500 years. The attached box presents the typical uses of turmeric in Indian medicine. These various uses reflect the large number of health benefits of turmeric. Of course, the different therapeutic uses of turmeric in Asia are not all supported by quality clinical studies. More than 6,000 scientific publications concern turmeric. The uses best supported scientifically are those for reducing inflammatory processes, improving glucose management (diabetes), and preventing cancer and cardiovascular diseases.

🔹Bioavailability

Curcumin is well tolerated at doses between 500 and 12,000 mg. The main obstacle encountered in clinical studies is its low bioavailability. Dietary turmeric contains on average only 2.8% curcumin and the maximum plasma concentration measured a few hours after ingestion of a 2000 mg dose of curcumin is only about 10 ng/ml (about 0.1%).

Curcuminoids are poorly absorbed, rapidly metabolized (glucuronidation) and eliminated. Their health benefits being very significant, more than 20 different approaches have been attempted to increase the bioavailability of curcumin. In general, the health benefits of formulated curcumin are superior.

This is why Vitoli Healthy Aging uses the “Longvida” formulation, which means “long life” and allows bioavailability 65 times greater (+6500%) than curcumin alone.

🔹Oxidation

Curcuminoids are powerful antioxidants; about 50 times more powerful than vitamin E. In humans, 90 mg of curcumin, before and after physical exercise, increases the antioxidant capacity of the blood.

The antioxidant properties of turmeric protect the cardiovascular system and contribute to its hepatoprotective and anticancer effects. Curcuminoids are also important anti-inflammatory agents. They interfere with many inflammation mediators.

🔹Powerful anti-inflammatory

Curcumin acts mainly through anti-inflammatory and antioxidant mechanisms, by modulating key pathways such as NF-κB and reducing inflammatory markers (e.g. CRP, TNF-α) — effects observed in several clinical trials and meta-analyses. It has documented anti-inflammatory and antioxidant effects, which help reduce the inflammatory burden associated with age. The anti-inflammatory properties of curcumin have shown encouraging results in animal models with ulcerative colitis, rheumatoid arthritis, pancreatitis and also cancer. In humans, a study on knee osteoarthritis (2014), involving 367 patients, demonstrated an effect comparable to that of Ibuprofen. Taking 1,500 mg per day of turmeric was comparable to taking 1,200 mg per day of ibuprofen.

It should be noted that patients who received turmeric reported fewer side effects (especially gastrointestinal problems).

🔹Aging

Although these anti-aging impacts in mammals remain mild or non-significant, curcumin stimulates mitogen-activated protein kinase (MAPK), or AMPK in English, which could slow aging by causing the inhibition of another metabolic pathway that promotes aging (mTOR). This impact also stimulates repair mechanisms. Also, several studies explore the effects of curcumin on brain inflammation, oxidative stress and neurotransmitters, with particular interest in cognitive disorders and mood.

🔹Metabolism and blood sugar

Reviews suggest that curcumin may improve certain metabolic parameters (fasting blood sugar, lipid profiles) and reduce systemic inflammation, which is relevant for overall metabolism and cardiovascular health.

A recent systematic analysis reports the benefits based on 103 clinical studies. This systematic review analyzed the effects of curcumin supplementation on metabolic parameters in humans, including fasting blood sugar, certain glycemic indices, lipid profile as well as inflammatory and oxidative markers. It concludes that taking curcumin can favorably modulate fasting blood sugar (FBS) and certain lipid parameters, as well as reduce inflammation and oxidative stress, suggesting a potential benefit in metabolic disorders.

N.B. In Vitoli Healthy Aging Synergy, highly bioavailable curcumin complements the action of resveratrol and hydroxytyrosol through a more marked reduction of inflammation and impacts on the mechanisms of cellular aging.

2.5) Passionflower (only in Vitoli Healthy Aging Synergy, 4:1 extract)

Janda et al., 2020; Ngan et al., 2011; Akhondzadeh et al., 2001; Ożarowski and Karpiński, 2021; Zhang et al., 2023; Lutchman et al., 2016A, Lutchman et al., 2016B; Dakik et al., 2019.

Passionflower (Passiflora incarnata) is a plant native to North America and Central America, used for centuries by Indigenous peoples for its calming and sedative effects. It was traditionally used to relieve anxiety, agitation and sleep disorders.

In the 16th century, Spanish missionaries introduced it to Europe, where it became symbolically associated with the “Passion of Christ,” hence its name. From the 18th century onward, it entered the European pharmacopoeia as a natural remedy against nervousness and insomnia.

Today, passionflower is widely used in herbal medicine in the form of infusions, extracts or supplements, mainly to promote relaxation, sleep and nervous balance.

🔹Relaxing effects

The majority of clinical trials found a reduction in anxiety and stress, without significant adverse effects.

🔹Metabolic effects

Vitexin and possibly other polyphenols in passionflower may improve insulin sensitivity while supporting cellular energy balance (via AMPK) and could thus contribute to slower cellular aging. These polyphenols may also inhibit pro-inflammatory pathways (NF-κB, cytokines), which could reduce low-grade chronic inflammation.

🔹Multiple effects

Passionflower extracts and compounds have been associated with antioxidant, anti-inflammatory, sedative/anxiolytic, sleep-supporting and neuroprotective pharmacological and physiological effects.

🔹Quebec discoveries

These multiple beneficial effects may come from a significant impact on cellular aging. Certain molecules from the specific passionflower extract used to produce Vitoli Healthy Aging Synergy have produced the best results ever published on slowing cellular aging. These molecules create a powerful synergistic effect with molecules from the Japanese knotweed extract also present in this product, increasing their cellular impacts by about 500%. Although the exact mechanisms of this slowing seem related to a new metabolic pathway, a new anti-aging cellular mechanism, the research team still discovered that this synergy is expressed through a strong increase in mitochondrial health (Lutchman et al., 2016A, Lutchman et al., 2016B; Dakik et al., 2019).

This synergy was patented and is offered to you exclusively in Vitoli Healthy Aging Synergy.