{"id":17445,"date":"2023-03-22T15:26:59","date_gmt":"2023-03-22T19:26:59","guid":{"rendered":"https:\/\/vitoli.ca\/?p=17445"},"modified":"2025-09-22T14:37:34","modified_gmt":"2025-09-22T18:37:34","slug":"therapeutic-uses-of-omega-3s-the-state-of-science","status":"publish","type":"post","link":"https:\/\/vitoli.ca\/en\/therapeutic-uses-of-omega-3s-the-state-of-science\/","title":{"rendered":"Therapeutic Uses of Omega-3s: The State of Science"},"content":{"rendered":"<p>Omega-3s are what we call, good fats. They have become one of the most widely consumed classes of supplements, and with good reason: it is virtually impossible to obtain therapeutic doses through diet. One article by our specialized pharmacist, and collaborator to the Vitoli blog, Mr. Jean-Yves Dionne, presented these unsaturated fatty acids in detail: <a href=\"https:\/\/vitoli.ca\/en\/a-practical-guide-to-omega-3s\/\">A Practical guide to omega-3s<\/a>.<\/p>\n<p>We will now focus on therapeutic uses by describing the state of the science. These are uses that can reduce the risk of disease or help correct physiological parameters such as blood pressure or blood lipid composition. We will therefore review 6 very high-quality scientific studies to focus on.<\/p>\n<ol>\n<li><strong>Liao <em>et al.<\/em>, 2019: Omega-3 and depression &#8211; Meta-analysis; 26 clinical studies, 2160 participants = therapeutic effect on improving depression.<\/strong>\n<ul>\n<li>Significant effects on symptoms of depression vs. placebo (P = 0.004):\n<ul>\n<li><strong>\u2265 1000 mg of EPA\/d<\/strong>:<\/li>\n<li>\u2265 60% EPA:<\/li>\n<\/ul>\n<\/li>\n<li>No significant effect from DHA.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p>Omega-3s thus have clearly demonstrated effects on depression, but the dosages must be high and mainly EPA.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<ol start=\"2\">\n<li><strong>Zhang <em>et al<\/em>., 2022: Omega-3 and hypertension (American Heart Association) Meta-analysis of 71 clinical trials, 4973 people.<\/strong>\n<ul>\n<li>Significant benefits between <strong>2000 to 3000 mg\/d<\/strong> of omega-3.<\/li>\n<li>Benefits superior to more than <strong>3000 mg\/d<\/strong> of omega-3.<\/li>\n<li>Benefits reach a threshold at 5000 mg\/d of omega-3.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p>Here, it is worth pointing out that the effect on hypertension becomes significant for doses higher than what is possible to take through food for the vast majority of people. It is difficult to consume more than 1000 mg of omega-3 on average per day, even when eating a lot of oily fish. On the other hand, very high dosages, over 5000 mg\/day are not necessary either. Note that the majority of supplements on the market do not achieve lower-level significance of more than 2000 mg\/day.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<ol start=\"3\">\n<li><strong>Weiberg <em>et al<\/em>., 2021: Omega-3 and cardiovascular health (Journal of the American College of Cardiology (JACC)) \u2013 JACC Focus seminar<\/strong>\n<ul>\n<li>Omega-3 supplementation may reduce the risk of CV disease in some patients.<\/li>\n<li>Omega-3 at doses of <strong>2 to 4 g\/d<\/strong> \u2193 blood triglycerides by <strong>25% to 40%<\/strong>.<\/li>\n<li>Other effects of omega-3s, other than lowering triglycerides, may contribute to their cardiovascular benefits.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p>Here is one of the most controversial applications (cardiovascular health), for which this study comes from one of the most credible sources on an international scale: The American College of Cardiology. It is possible that the controversy is related to the high dosages necessary to have a significant impact (more than 2000 mg\/day); a dosage that is not reached by the majority of supplements on the market.<\/p>\n<p>&nbsp;<\/p>\n<ol start=\"4\">\n<li><strong>Sigaux <em>et al.<\/em>, 2022: Omega-3 and inflammatory rheumatoid diseases &#8211; Systematic review and meta-analysis: 30 clinical studies, 1420 participants, 3 to 6 months.<\/strong>\n<ul>\n<li>Therapeutic dose <strong>\u2265 2000 mg\/d<\/strong>. Significant effects compared to placebo on:\n<ul>\n<li>The number of painful, swollen, and tender joints,<\/li>\n<li>The level of disease activity (assessment for 28 joints), and<\/li>\n<li>The results of the health assessment questionnaire.<\/li>\n<li>Better impact of fish omega-3s.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p>Inflammation issues affect both joint pain and mobility. Again, we are at more than 2000 mg\/day for a therapeutic dose and the best impact of fish omega-3s is probably related to their easily assimilated form. Plant omega-3s must be converted to be assimilated by our cells and the conversion rate is said to be as low as 5-10%.<\/p>\n<p>&nbsp;<\/p>\n<ol start=\"5\">\n<li><b>Firouzabadi <em>et al.<\/em>, 2022: Omega-3, pregnant women, lactation and infancy \u2013 Systematic review and meta-analyses; 28 meta-analyses; 672 clinical studies, 273,523 participants<\/b><strong>.<\/strong>\n<ul>\n<li>Moderate to high evidence:\n<ul>\n<li>\u2193 risk of preeclampsia,<\/li>\n<li>\u2193 the risks of low birth weight,<\/li>\n<li>\u2191 in head circumference (when taken during pregnancy).<\/li>\n<li>\u2193 severe retinopathy of prematurity,<\/li>\n<li>\u2193 cholestasis (bile) (when used in infancy).<\/li>\n<\/ul>\n<\/li>\n<li>Favorable effects on:\n<ul>\n<li>\u2193 risk of preterm birth,<\/li>\n<li>\u2193 risk of depression during or after pregnancy,<\/li>\n<li>Improved control of blood sugar and inflammation for pregnant women,<\/li>\n<li>Improvement of the immune system (allergies) and visual ability in children.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p>Here with the sum of scientific demonstrations and the level of certainty of the benefits, it is difficult to understand that quality omega-3 supplements are not automatically recommended to all pregnant women. Note that it is advisable to stop taking it about one month before delivery.<\/p>\n<p>&nbsp;<\/p>\n<ol start=\"6\">\n<li><strong>Lafuente <em>et al.<\/em>, 2021: Omega-3 and visual health \u2013 Antioxidant role and neuroprotection for eye diseases (review).<\/strong>\n<ul>\n<li>The role of ADH in reducing oxidation and protecting vision has been studied in different types of models, particularly for proliferative diabetic retinopathy, macular degeneration, and glaucoma.<\/li>\n<li><strong>High doses of DHA<\/strong> are needed to achieve benefits (<strong>1050 mg\/d<\/strong>).<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p>Here is one last application that is less well supported from a scientific point of view, but for which we have seen fit to bring you the information since there are not many natural solutions for vision problems such as dry eyes which affects a large part of the population.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Conclusion<\/strong><\/p>\n<p>Omega-3s are unquestionably essential for the proper functioning of our cells and they can even help in several facets of health if they are taken in sufficient quantity. Unfortunately, many people consume low-concentration products that do not achieve therapeutic doses. It is for this reason that we have decided to make BASE Omega-3 available:<\/p>\n<ul>\n<li>BASE Standard = natural balance: 1635\/540 mg EPA\/DHA, 2450 mg of total omega-3\/day.<\/li>\n<li>BASE enriched with DHA: 530\/2660 mg EPA\/DHA, 3560 mg of total omega-3\/day.<\/li>\n<li>BASE enriched with EPA: 2650\/530 mg EPA\/DHA, 3450 mg of total omega-3\/day.<\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><\/p>\n<p>Do not hesitate to write to us if you need advice; it is always a pleasure to be of service!<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Other Suggested Articles: <\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/vitoli.ca\/en\/a-better-understanding-of-the-quality-of-vitoli\/\">A Better Understanding of the Vitoli Quality<\/a><\/li>\n<li><a href=\"https:\/\/vitoli.ca\/en\/the-natural-and-effective-solution-against-pain-and-inflammation\/\">A Natural and Effective Solution Against Pain and Inflammation<\/a><\/li>\n<li><a href=\"https:\/\/vitoli.ca\/en\/vitoli-immunity-the-most-complete-product\/\">Vitoli Immunity: The Most Complete Product<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>\u00a0&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ul>\n<li>Firouzabadi <em>et al<\/em>, 2022. The effects of omega-3 polyunsaturated fatty acids supplementation in pregnancy, lactation, and infancy: An umbrella review of meta-analyses of randomized trials. Pharmacol Res. 2022 Jan 29;177:106100.<\/li>\n<li>Lafuente <em>et al<\/em>, 2021. Antioxidant Activity and Neuroprotective Role of Docosahexaenoic Acid (DHA) Supplementation in Eye Diseases That Can Lead to Blindness: A Narrative Review. Antioxidants (Basel). 2021 Mar 5;10(3):386. Leonov et al, 2015. Longevity extension by phytochemicals. Molecules. 2015 Apr 13;20(4):6544-72.<\/li>\n<li>Liao <em>et al<\/em>, 2019. Efficacy of omega-3 PUFAs in depression: A meta-analysis. Transl Psychiatry. 2019 Aug 5;9(1):190.<\/li>\n<li>Sigaux <em>et al<\/em>, 2022. Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis. Arthritis Res Ther. 2022 May 7;24(1):100.<\/li>\n<li>Weinberg <em>et al<\/em>, 2021. Cardiovascular Impact of Nutritional Supplementation With Omega-3 Fatty Acids &#8211; JACC Focus Seminar. J Am Coll Cardiol. 2021 Feb 9;77(5):593-608.<\/li>\n<li>Zhang <em>et al<\/em>, 2022. Omega-3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2022 Jun 7;11(11):e025071.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>We will focus on therapeutic uses by describing the state of the science. These are uses that can reduce the risk of disease or help correct physiological parameters such as blood pressure or blood lipid composition. We will therefore review 6 very high-quality scientific studies to focus on.<\/p>\n","protected":false},"author":5,"featured_media":38095,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[43],"tags":[39,206],"class_list":["post-17445","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-eric-simard-en","tag-general-health","tag-omega-3-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Therapeutic Uses of Omega-3s: The State of Science - Vitoli<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/vitoli.ca\/en\/therapeutic-uses-of-omega-3s-the-state-of-science\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Therapeutic Uses of Omega-3s: The State of Science - Vitoli\" \/>\n<meta property=\"og:description\" content=\"We will focus on therapeutic uses by describing the state of the science. 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